Seagen

Scientist Bioanalytical Mass Spectrometry

Development - Bothell, United States

Seagen is a global, multi-product biotechnology company dedicated to developing and commercializing transformative cancer medicines. As the industry leader in antibody-drug conjugate (ADC) technology, we pioneered a new generation in the science of harnessing antibodies to deliver cell-killing agents directly to cancer cells. Seagen’s dedication to improving the lives of cancer patients goes beyond science, and we believe that every employee has a role in contributing to this mission. By working together with a shared dedication and diverse perspectives, we are able to reach our full potential and make a real difference in the world. Seagen is a fast-growing company and has an abundance of opportunities available for you to grow your career. Put your passion to work at Seagen and join us!

Summary

The Mass Spectrometry Bioanalysis and Technology (MSBT) group within the Translational Sciences Department is seeking a highly motivated and experienced scientist who will focus on development of novel mass spectrometry based bioanalytical methods. Assay development duties will include utilizing micro/nano flow chromatography with high resolution and accurate mass (HRAM) mass spectrometry, as well as highly multiplexed methods for analysis of low samples volumes. This position will also facilitate method development/transfer, validation and sample testing under regulated conditions at CRO partners. The ideal candidate will have experience in the following: qualitative and quantitative mass spectrometry, nano/micro liquid chromatography and HRAM mass spectrometry method development and troubleshooting and multiplexed assay development utilizing low sample volumes, sample extraction/preparation from a range of matrices. This position will involve designing experiments to answer unique bioanalytical questions, evaluate complex data sets, manage timelines and priorities across multiple programs, and have strong communication skills.

Principal Responsibilities:

• Develop unique sample preparation and LC-MS based bioanalytical methods utilizing state-of-the-art technologies to address fundamental questions for lead large and small molecules.
• Implement workflows for developed methods, including report templates with strict attention to quality control.
• Perform sample testing, as well as mentor and train colleagues in new methodologies.
• Perform and coordinate troubleshooting and maintenance on LC systems and mass spectrometers.
• Generate data and reports to contribute to regulatory documents and filings.
• Acts as subject matter expert in the overseeing of method transfers, validations and sample testing at CROs.
• Work collaboratively with CROs to manage outsourced projects and deliverables while adhering to internal timelines.
• Contribute to development and maintenance of collaborative tools for tracking and managing outsourced studies
• Contribute to meetings to ensure alignment with internal/external stakeholders.
• Strong organizational skills, as well as ability to effectively communicate and present in small groups and for large audiences.
• Represent team in highly collaborative groups across research, translational sciences and clinical development.
• Desire to work in a collaborative, team-oriented environment.

Required Qualifications:

• Hands-on experience with HRAM mass spectrometry and nano/micro flow liquid chromatography.
• Prior experience with multiplex method development utilizing small sample volumes.
• Experience with sample extraction/preparation from a variety of biological matrices.
• Strong analytical, problem-solving, and decision-making skills.

Preferred Qualifications:

• Ph.D. plus 0-2 years of relevant experience, or equivalent industry experience, in mass spectrometry.
• Experience using Sciex and Thermo instrumentation software.
• Functional knowledge of MS data analysis software, such as Sciex OS, Mass Frontier, Compound Discoverer, Protein Metrics, Biopharma Finder, Skyline, EncylopeDIA, and MaxQuant.
• Familiarity with guidance documents for method development and validations.
• Industry experience, or familiarity with GLP environment.

As the leading employer in our industry in the Pacific Northwest, Seagen is proud to offer a competitive total compensation package as well as a comprehensive benefits program designed to support the whole lives of our employees and their families. Benefits include medical, vision and dental coverage, group and supplemental life insurance, 401(k) with company match, tuition reimbursement, relocation assistance and much more. To learn more about Seagen, please visit www.seagen.com.

Seagen is an equal opportunity employer. All qualified applications will receive consideration for employment without regard to race, age, gender identity, sexual orientation, color, religion, sex, marital status, national origin, protected veteran status, disability status, or any other status protected by federal, state, or local law.

To prevent the spread of COVID-19, and as an integral part of its public health and safety measures, Seagen requires that all newly-hired employees be fully vaccinated against COVID-19 before commencing employment, subject to reasonable accommodation and other requirements of applicable federal, state, and local law.

Apply:

Seagen

Seagen is an Equal Opportunity Employer

Submitted: 07/15/2022